Ãíùóôéêü Ðåäßï
- Organic Chemistry
- Development of novel synthetic methodologies towards organic compounds
- Design and synthesis of bioactive compounds and natural product analogues
- Study of the biological activity of organic compounds
- Spectroscopic techniques for the structural characterization of organic molecules (NMR, MS, FT-IR, UV-Vis).
ÓðïõäÝò
- Ph. D. Chemistry, Laboratory of Organic Chemistry, Department of Chemical Engineering, National Technical University of Athens (NTUA), Athens, Greece (1998)
- BSc Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Greece (1990)
ÅñåõíçôéêÜ ÅíäéáöÝñïíôá
- Organic Chemistry
- Development of novel synthetic methodologies towards organic compounds
- Design and synthesis of bioactive compounds and natural product analogues
- Study of the biological activity of organic compounds
- Spectroscopic techniques for the structural characterization of organic molecules (NMR, MS, FT-IR, UV-Vis).
ÅðéëåãìÝíåò Äçìïóéåýóåéò:
- S. Moussouni, A. Detsi, M. Majdalani, D. P. Makris, P. Kefalas “Crude peroxidase from onion solid waste as a tool for organic synthesis. Part I: cyclisation of 2’,3,4,4’,6’-pentahydroxy-chalcone into aureusidin”, Tetrahedron Lett. 2010, 51, 4076–4078.
- M. Roussaki, C. A. Kontogiorgis, D. Hadjipavlou-Litina, S. Hamilakis, A. Detsi, “A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity”, Bioorg. Med. Chem. Lett. 2010, 20, 3889–3892
- A. Detsi, M. Majdalani, C. A. Kontogiorgis, D. Hadjipavlou-Litina, P. Kefalas, ‘Natural and synthetic 2’-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity’, Bioorg. Med. Chem. 2009, 17, 8073-8085.
- M. Koufaki, A. Detsi and C. Kiziridi, “Multifunctional Lipoic Acid Conjugates”, Curr. Med. Chem. 2009, 16, 4728-4742.
- G. Melagraki, A. Afantitis, O. Igglessi-Markopoulou, A. Detsi, M. Koufaki, C. Kontogiorgis, D. Hadjipavlou-Litina,” Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts”, Eur. J. Med. Chem. 2009, 44, 3020-3026.
- T. Calogeropoulou; P. Angelou; A. Detsi; I. Fragiadaki; E. Scoulica, “Design and Synthesis of Potent Antileishmanial Cycloalkylidene-Substituted Ether Phospholipid Derivatives” J. Med. Chem. 2008, 51, 897-908.
- Á. Detsi, D. Bouloumbasi, K. C. Prousis, M. Koufaki, G. Athanasellis, G. Melagraki, A. Afantitis, O. Igglessi-Markopoulou, C. Kontogiorgis, D. J. Hadjipavlou-Litina, ’’Design and Synthesis of Novel Quinolinone-3-aminoamides and Their á-Lipoic Acid Adducts as Antioxidant and Anti-inflammatory Agents’’ J. Med. Chem. 2007, 50, 2450-2458.
- S. Kikionis, K. C. Prousis, A. Detsi, Ï. Igglessi-Markopoulou, ‘’A novel synthetic approach to the thiotetronic ring system, the key intermediate for thiolactomycin analogues’’ ARKIVOC, 2006, 12, 28-37.
- Á. Detsi, V. Roussis, A. Tsotinis, C. Roussakis, T. Calogeropoulou "A concise approach to benzoic acid derivatives bearing an á,â-unsaturated ketone substituent: synthesis of methyl taboganate” Synlett, 2005, 20, 3131-3135.
- K. C. Prousis, A. Detsi and O. Igglessi-Markopoulou “A Novel Traceless Solid Phase Approach to Functionalized Tetramic Acids and 2-Amino-4-pyrrolinones“ Synlett, 2005, 2763-2767.
- M. Koufaki, A. Detsi, E. Theodorou, C. Kiziridi, T. Calogeropoulou, A. Vassilopoulos , A. P. Kourounakis, E. Rekka, P N. Kourounakis, C. Gaitanaki , P. Papazafiri "Synthesis of Chroman Analogues of Lipoic Acid and Evaluation of their Activity against Reperfusion Arrhythmias", Âioorg. Med. Chem., 2004, 12, 4835-4841.
- L. Zikou, G. Athanasellis, A. Detsi, A. Zografos, C. Mitsos, O. Igglessi-Markopoulou "Novel Short-step Synthesis of Functionalized 4-Hydroxy-2-Quinolones Using 1-Hydroxybenzotriazole Methodology" Bull. Chem.Soc.Japan, 2004, 77, 1505-1508.
- G. Athanasellis, G. Melagraki, H. Chatzidakis, A. Afantitis, A. Detsi, O. Igglessi-Markopoulou, J. Markopoulos "Novel short step synthesis of functionalized ã-Phenyl-â-hydroxybutenoates and their cyclization to 4-hydroxy coumarins via the N-hydroxybenzotriazole methology", Synthesis, 2004, 11, 1775-1782.
- Á. Detsi, P. Emirtzoglou, K. Proussis, A. Nikolopoulos, V. Skouridou and Olga Igglessi-Markopoulou "Solid Phase Synthesis of Substituted 2-Amino-4-Pyrrolinones via Spontaneous Postcleavage Cyclization" Synlett, 2004, 2, 353-355.
- C.-K. Skylaris, A. Detsi, J. Markopoulos, O. Igglessi-Markopoulou "Density functional and ab initio study of the tautomeric forms of 3-acetyl tetronic and 3-acetyl tetramic acids", Chem. Phys., 2003, 293 (3), 355-363.
- Calogeropoulou T., Detsi A., Lekka E. and Koufaki M., "Strategies in the design of prodrugs of anti-HIV agents", Current Topics in Medicinal Chemistry, 2003, 3 (13), 1467-1495.
- G. Athanasellis, A. Detsi, K. Prousis, O. Igglessi-Markopoulou, J. Markopoulos "A novel access to 2-aminofuranones via cyclisation of functionalized ã-hydroxy-á-butenoates derived from N-hydroxybenzotriazole esters of á-hydroxy acids" Synthesis, 2003, 13, 2015-2022.
- Á. Detsi, A. Afantitis, G. Athanasellis, J. Markopoulos, O. Igglessi-Markopoulou and C.-K. Skylaris "Cyclisation of Novel Amino Oxo Esters to Tetramic Acids- Density Functional Theory Study of the Reaction Mechanism" Eur. J. Org. Chem., 2003, 4593-4600.
- Avlonitis N., Lekka E., Detsi A., Koufaki M., Calogeropoulou T., Skoulika E., Siapi E., Kyrikou I., Mavromoustakos T., Tsotinis A and Makriyannis A. "Antileishmanial Ring-Substituted Ether Phospholipids", J. Med. Chem., 2003, 46, 755-767.
- Á. Detsi, M. Koufaki and T. Calogeropoulou, "Synthesis of (Z)-4-hydroxytamoxifen and (Z)-2-{4-[1-(p-hydroxyphenyl)-2-phenyl]-1-butenyl} phenoxyacetic acid", J. Org. Chem., 2002, 67, 4608-4611.
- M. Koufaki, T. Calogeropoulou, A. Detsi, A. Roditis, A. P. Kourounakis, P. Papazafiri, K. Tsiakitzis, C. Gaitanaki, I. Beis and I. Kourounakis, "Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias", J. Med. Chem., 2001, 44, 4300.
- Á. Detsi, E. Gavrielatos, M.-A. Adam, O. Igglessi-Markopoulou, J. Markopoulos, M. Theologitis and M. Papadopoulos, "Synthesis and tautomeric studies of N-urethane protected ã-amino functionalized butenoates using NMR, X-Ray crystallography and ab initio calculations", Eur. J. Org. Chem., 2001, 4337.
- Á. Detsi, M.Micha-Screttas and O.Igglessi-Markopoulou, "Synthesis of N-alkoxy-carbonyl-3-substituted tetramic acids and functionalized enols via C-acylation reactions of active methylene compounds with N-hydroxysuccinimide esters of N-alkoxycarbonyl-á-aminoacids", J. Chem. Soc. Perkin Trans. 1, 1998, 2443.
- V.Delieza, A.Detsi, V.Bardakos and O.Igglessi-Markopoulou, "Reactions of 2-methyl-4H-pyrido-[2,3-d][3,1]-oxazin-4-one with active methylene compounds. A new efficient route to 3-substituted-4-hydroxy-1,8-naphthyridin-2-ones", J. Chem. Soc., Perkin Trans. 1, 1997, 1487.
- A. Detsi, V.Bardakos, J.Markopoulos and O.Igglessi-Markopoulou, "Reactions of 2-methyl-3,1-benzoxazin-4-one with active methylene compounds. A new route to 3-substituted-4-hydroxy-quinolin-2-ones", J. Chem. Soc., Perkin Trans. 1, 1996, 2909.
- Á. Detsi, J.Markopoulos and O.Igglessi-Markopoulou, "Reactions of N-hydroxy-succinimide esters of N-alkoxycarbonyl-á-aminoacids with active methylene compounds. Synthesis of 3-substituted tetramic acids", Chem. Comm., 1996, 1323.